Genetic basis for Anorexia Nervosa : Holland et al (1984)

Aims: To establish whether there is any genetic basis for the eating disorder Anorexia Nervosa (AN)

Procedure: 34 pairs of twins were studied in a clinical session to establish how many of the individuals suffered suffered from AN.

Findings: A concordance rate of 55% for MZ twins was reported, compared to a rate of 7% for DZ twins.

Conclusion: AN is strongly influenced by genetic factors, although since the concordance was not 100%, there must be other influences as well.

Strength: The fact that the concordance was not 100% provides hope to sufferers that their condition isn't an inescapable result of their biological makeup.

Weakness 1:The sample was very small, and the results may not generalize.

Weakness 2: It may be that factors other than genes are influencing these results; for example identical twins are likely to be treated differently from non-identical twins, and this may contribute to behavioural abnormalities.

See class notes for 13-Mar.


Study sheets index